Wetherby Prep started in September 2004 with 24 pupils in Year 4. Since then, the school has grown organically and now provides education to 325 boys in Years 3 to 8. In September 2009 the school moved to larger premises at Bryanston Square. Here the school has been able to develop, grow and continue to provide first class education to its boys. In 2015, the School acquired its own sporting facility – Wetherby Sports Ground – in East Acton.
Wetherby Prep retains close links with the well-established Wetherby School in Pembridge Square and many boys transfer between the two schools at the end of Year 3. In 2015, Wetherby Senior School was opened in Marylebone and in 2017, Wetherby Pembridge New York opened in Upper East Side, New York City.